SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE)
Sorafenib tosylate
CAS: 475207-59-1;4750207-59-1
Molecular Formula: C28H24ClF3N4O6S
SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE) - Names and Identifiers
| Name | Sorafenib tosylate |
| Synonyms | BAY43-9006 BAY 43-9006 SORAFENIB-D3 SORAFENIB TOSYLATE Sorafenib tosylate Sorafinib mesylate Sorafenib Tosylate(Bay 43-9006,Nexavar) SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE) N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea Tolsylate 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate) 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate |
| CAS | 475207-59-1 4750207-59-1 |
| EINECS | 641-758-8 |
SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE) - Physico-chemical Properties
| Molecular Formula | C28H24ClF3N4O6S |
| Molar Mass | 637.03 |
| Melting Point | 229-232°C |
| Solubility | Soluble in water (<1 mg/ml) at 25 °C, DMSO (127 mg/ml) at 25 °C, and ethanol (<1 |
| Appearance | solid |
| Color | Off-white |
| Storage Condition | 2-8°C(protect from light) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Use | An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases. |
SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE) - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| HS Code | 29159000 |
SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE) - Introduction
Sorafenib Tosylate are tyrosine kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitors, acting simultaneously on Raf-1,wtBRAF and V599EBRAF, with IC50 of 6 nM, 22 nM and 38 nM, respectively.
Last Update：2022-10-16 17:25:22
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